Package: wppi
Type: Package
Title: Weighting protein-protein interactions
Version: 1.18.0
Authors@R: c(
    person(
        given = "Ana",
        family = "Galhoz",
        role = c("cre", "aut"),
        email = "ana.galhoz@helmholtz-muenchen.de",
        comment = c(ORCID = "0000-0001-7402-5292")),
    person(
        given = "Denes",
        family = "Turei",
        role = "aut",
        email = "turei.denes@gmail.com",
        comment = c(ORCID = "0000-0002-7249-9379")),
    person(
        given = "Michael",
        family = "P. Menden",
        role = "aut",
        email = "michael.menden@helmholtz-muenchen.de",
        comment = c(ORCID = "0000-0003-0267-5792")),
    #
    # Copyright holders
    person("Albert", "Krewinkel", role = c("ctb", "cph"), 
         comment = "pagebreak Lua filter")
    )
Description: Protein-protein interaction data is essential for omics
        data analysis and modeling. Database knowledge is general, not
        specific for cell type, physiological condition or any other
        context determining which connections are functional and
        contribute to the signaling. Functional annotations such as
        Gene Ontology and Human Phenotype Ontology might help to
        evaluate the relevance of interactions. This package predicts
        functional relevance of protein-protein interactions based on
        functional annotations such as Human Protein Ontology and Gene
        Ontology, and prioritizes genes based on network topology,
        functional scores and a path search algorithm.
License: MIT + file LICENSE
URL: https://github.com/AnaGalhoz37/wppi
BugReports: https://github.com/AnaGalhoz37/wppi/issues
biocViews: GraphAndNetwork, Network, Pathways, Software, GeneSignaling,
        GeneTarget, SystemsBiology, Transcriptomics, Annotation
Encoding: UTF-8
VignetteBuilder: knitr
Depends: R(>= 4.1)
Imports: dplyr, igraph, logger, methods, magrittr, Matrix, OmnipathR(>=
        2.99.8), progress, purrr, rlang, RCurl, stats, tibble, tidyr
Suggests: knitr, testthat, rmarkdown
RoxygenNote: 7.1.1
NeedsCompilation: no
Config/pak/sysreqs: libglpk-dev make libicu-dev libxml2-dev libssl-dev
        libx11-dev
Repository: https://bioc-release.r-universe.dev
Date/Publication: 2025-10-29 15:08:00 UTC
RemoteUrl: https://github.com/bioc/wppi
RemoteRef: RELEASE_3_22
RemoteSha: c2e3b83ea1b2d14fe5a8668c56ec7091c38f8411
Packaged: 2025-11-24 16:17:11 UTC; root
Author: Ana Galhoz [cre, aut] (ORCID: <https://orcid.org/0000-0001-7402-5292>),
  Denes Turei [aut] (ORCID: <https://orcid.org/0000-0002-7249-9379>),
  Michael P. Menden [aut] (ORCID:
    <https://orcid.org/0000-0003-0267-5792>),
  Albert Krewinkel [ctb, cph] (pagebreak Lua filter)
Maintainer: Ana Galhoz <ana.galhoz@helmholtz-muenchen.de>
Built: R 4.5.2; ; 2025-11-24 16:19:28 UTC; windows
