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wSIR

This is the development version of wSIR; to use it, please install the devel version of Bioconductor.

Weighted Sliced Inverse Regression (wSIR) for supervised dimension reduction of spatial transcriptomics and single cell gene expression data


Bioconductor version: Development (3.24)

Weighted Sliced Inverse Regression (wSIR) is a supervised dimension reduction algorithm for spatial transcriptomics gene expression data. For a provided gene expression matrix and dataframe of each cell's spatial coordinates, wSIR creates a low-dimensional representation of the gene expression data that preserves the ability to predict spatial coordinates that was present in the gene expression data. Furthermore, wSIR provides interpretable loadings which allow for projection of new single-cell gene expression data into a low-dimensional space which preserves the spatial information present in the gene expression data.

Author: Max Woollard [aut, cre] ORCID iD ORCID: 0009-0000-6319-6926 , Pratibha Panwar [ctb] ORCID iD ORCID: 0000-0002-7437-7084 , Linh Nghiem [aut] ORCID iD ORCID: 0000-0003-2874-9067 , Shila Ghazanfar [aut] ORCID iD ORCID: 0000-0001-7861-6997

Maintainer: Max Woollard <mwoo5086 at uni.sydney.edu.au>

Citation (from within R, enter citation("wSIR")):

Installation

To install this package, start R (version "4.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("wSIR")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("wSIR")
wSIR supervised dimension reduction HTML R Script
Reference Manual PDF
NEWS Text
LICENSE Text

Details

biocViews CellBasedAssays, DimensionReduction, GeneExpression, Regression, SingleCell, Software, Spatial, Transcriptomics
Version 0.99.9
In Bioconductor since BioC 3.24 (R-4.6)
License MIT + file LICENSE
Depends R (>= 4.4.0)
Imports magrittr (>= 2.0), ggplot2 (>= 3.5.1), umap (>= 0.2.10), vctrs (>= 0.6), stringr (>= 1.5.1), distances (>= 0.1.11), Rcpp (>= 1.0.11), doBy (>= 4.6.0), BiocParallel(>= 1.38.0), rlang, methods, BiocGenerics(>= 0.50.0), SummarizedExperiment(>= 1.34.0), SingleCellExperiment(>= 1.26.0), SpatialExperiment(>= 1.14.0)
System Requirements
URL https://sydneybiox.github.io/wSIR https://github.com/SydneyBioX/wSIR
Bug Reports https://github.com/sydneybiox/wSIR/issues
See More
Suggests knitr, BiocStyle, class, testthat (>= 3.0.0)
Linking To Rcpp, RcppArmadillo
Enhances
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package wSIR_0.99.9.tar.gz
Windows Binary (x86_64) wSIR_0.99.9.zip
macOS Binary (big-sur-x86_64) wSIR_0.99.9.tgz
macOS Binary (sonoma-arm64) wSIR_0.99.9.tgz
Source Repository git clone https://git.bioconductor.org/packages/wSIR
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/wSIR
Bioc Package Browser https://code.bioconductor.org/browse/wSIR/
Package Short Url https://bioconductor.org/packages/wSIR/
Package Downloads Report Download Stats